Natural Homologs of Gramicidin S. II. Synthesis of Gramicidin S-2 and S-3
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چکیده
منابع مشابه
Synthesis and biological evaluation of gramicidin S dimers.
The design and synthesis of analogues of the cyclic beta-sheet gramicidin S (GS), having additional functionalities in their turn regions, is reported. The monomeric GS analogues were transformed into dimers and their activities towards biological membranes, through antimicriobial and hemolytic assays, were evaluated. Finally, conductivity measurements have been performed to elucidate ion chann...
متن کاملHybrid analogues of gramicidin S and gratisin.
tions with C2 symmetry and results in disruption of its cell membrane.1-9,13) In addition, no resistance has been found for the antibiotics, because it requires significant alteration of the lipid composition of the cell membrane.14) In view of the fact that widespread antibiotic resistance has become a serious threat to public health15-18), these amphiphilic antibiotics are attractive targets ...
متن کاملArginine regulation of gramicidin S biosynthesis.
Several amino acids are known to affect the gramicidin S producer Bacillus brevis ATCC 9999 with respect ot growth, soluble gramicidin S synthetase formation, antibiotic production, or a combination of these. Our studies confirmed that arginine has paradoxical effects on the B. brevis fermentation; it markedly increased growth and antibiotic production, yet decreased the soluble heavy gramicidi...
متن کاملThe free amino group of gramicidin S.
on the other hand, maintain that both amino and carboxyl groups are present and that the 8-amino group of the ornithine residue is not free. Their evidence for this latter point, nevertheless, is not very convincing and the problem was clearly one which could be readily settled by applying the new dinitrofluorobenzene (DNFB) method (Sanger, 1945). Accordingly at Dr Synge's suggestion, the prese...
متن کاملPermeability of dormant spores of Bacillus subtilis to gramicidin S.
Gramicidin S, dissolved in ethanol, penetrated into the inside of the dormant spores of Bacillus subtilis, had a partial inhibitory effect on L-alanine-initiated germination and completely inhibited their outgrowth and vegetative growth. The activity of particulate NADH oxidase of the antibiotic-treated dormant spores was also influenced significantly. Abnormal morphological changes were observ...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1985
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.58.331